Description
Product Characteristics:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.This antibody is reactive with 14-3-3 Alpha/Beta/Gamma/Delta/Epsilon.
Subcellular location: Cytoplasm
Synonyms: 14 3 3 protein T cell, 14 3 3 protein tau, 14 3 3 protein theta, 14 3 3 tau, 14 3 3 theta, 14-3-3 protein T-cell, 14-3-3 protein tau, 14-3-3 protein theta, 1433T_HUMAN, 1C5, HS1, KCIP1, Protein HS1, Protein kinase C inhibitor protein 1, Protein tau, tyr3/trp5 monooxygenase activation protein, theta, Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, theta polypeptide, YWHAQ.
Target Information: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]